Prognostic Implications of Manual versus Digital PD-L1 Expression in pT3 and pT4 Colon Carcinoma - Takeaways - MDSpire

Prognostic Implications of Manual versus Digital PD-L1 Expression in pT3 and pT4 Colon Carcinoma

  • By

  • Dea Natalie Munch Jepsen

  • Marianne Bøgevang Jensen

  • Astrid Louise Bjørn Bennedsen

  • Trine Lønbo Grantzau

  • Thomas Thiilmark Eriksen

  • Jens Ole Eriksen

  • Michael Bzorek

  • Ismail Gögenur

  • Anne-Marie Kanstrup Fiehn

  • November 21, 2025

  • 0 min

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  • 1

    PD-L1 expression is linked to worse survival outcomes in various solid tumors, including colorectal cancer (CRC), but its prognostic value remains controversial.

  • 2

    This study evaluated PD-L1 as a prognostic marker in patients with pT3 and pT4 colon cancer using both manual and digital scoring methods.

  • 3

    A total of 188 patients with surgically resected pT3 or pT4 colon cancer were included, with strict exclusion criteria applied to ensure data integrity.

  • 4

    Different scoring methods for PD-L1 expression, including tumor proportion score and immune cell score, were utilized to assess their association with overall survival.

  • 5

    The study highlights the need for standardized PD-L1 evaluation methods in CRC to improve prognostic assessments and treatment strategies.

Original Source(s)

Prognostic Implications of Manual versus Digital PD-L1 Expression in pT3 and pT4 Colon Carcinoma

  • by Dea Natalie Munch Jepsen, Marianne Bøgevang Jensen, Astrid Louise Bjørn Bennedsen, Trine Lønbo Grantzau, Thomas Thiilmark Eriksen, Jens Ole Eriksen, Michael Bzorek, Ismail Gögenur, Anne-Marie Kanstrup Fiehn

  • November 21, 2025

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