NOTCH3 drives fatty acid oxidation and ferroptosis resistance in aggressive meningiomas

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NOTCH3 is a key driver of tumor growth and radiation resistance in aggressive meningiomas, highlighting its potential as a therapeutic target.
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Activation of NOTCH3 influences lipid metabolism in meningiomas by depleting fatty acids, which are essential for fatty acid oxidation.
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The metabolic changes induced by NOTCH3 activation protect meningioma cells from ferroptosis, contributing to their malignancy.
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Meningiomas expressing NOTCH3 are associated with a poor prognosis due to their enhanced survival mechanisms.
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The study emphasizes the need for further research into the metabolic consequences of NOTCH3 activation in meningiomas.

Journal Of Neuro-Oncology

by Nishanth S. Sadagopan, Mateo Gomez, Shashwat Tripathi, Leah K. Billingham, Susan L. DeLay, Martha A. Cady, Harrshavasan T. S. Congivaram, Tzu-Yi Chia, Hanxiao Wan, Si Wang, David R. Raleigh, Faith C. Kaluba, Evan C. Lien, Amy B. Heimberger, Catalina Lee-Chang, Mark W. Youngblood, Stephen T. Magill, Jason M. Miska
September 9, 2025

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