Weight Regain Rapidly Follows GLP-1 Cessation

Systematic review finds most lost weight returns within two years of stopping weight management medication

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Weight regain occurs rapidly after stopping GLP-1 medications, with patients projected to return to baseline weight in less than two years.
2

Participants lost an average of 8.3 kg during treatment, but regained weight at a mean rate of 0.4 kg per month post-cessation.
3

Improvements in cardiometabolic markers diminish quickly after discontinuation of GLP-1 receptor agonists, similar to weight regain.
4

Real-world discontinuation rates for GLP-1 receptor agonists are high, with around half of patients stopping treatment within a year.
5

Long-term use of weight management medications may be necessary to sustain benefits, alongside behavioral support for obesity treatment.

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