Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies - Takeaways - MDSpire

Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies

  • By

  • Zohreh Salari

  • Ahmad Khosravi

  • Arezo Riahi

  • Elaheh Molaakbari

  • Ehsan Salarkia

  • Ali Reza Keyhani

  • Samira Sohbati

  • Ghazal Mansouri

  • Mina Khosravi

  • Mohammad Zarif

  • Mohammad Amin Raeisi Estabragh

  • November 26, 2025

  • 0 min

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  • 1

    Breast cancer is a leading cause of cancer-related mortality among women, with triple-negative breast cancer having a high risk of recurrence and metastasis.

  • 2

    Cisplatin induces apoptosis through DNA cross-linking but faces challenges due to acquired resistance mechanisms in breast cancer treatment.

  • 3

    Mefloquine targets lysosomal and mitochondrial pathways, enhancing apoptosis and exhibiting anti-angiogenic effects in breast cancer cells.

  • 4

    Niosomes improve drug delivery and bioavailability for anticancer therapies, potentially enhancing the efficacy of combined mefloquine and cisplatin treatment.

  • 5

    The study evaluates the synergistic effects of cisplatin and mefloquine in breast cancer, focusing on cellular responses and molecular signaling.

Original Source(s)

Comparative Analysis of Niosomal Mefloquine and Cisplatin on Apoptosis and Angiogenesis in Breast Cancer: Insights from In Vitro and In Silico Studies

  • by Zohreh Salari, Ahmad Khosravi, Arezo Riahi, Elaheh Molaakbari, Ehsan Salarkia, Ali Reza Keyhani, Samira Sohbati, Ghazal Mansouri, Mina Khosravi, Mohammad Zarif, Mohammad Amin Raeisi Estabragh

  • November 26, 2025

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