Neuroinflammatory mechanisms and pharmacological advances in autism spectrum disorder: from inflammatory pathways to targeted interventions - Takeaways - MDSpire
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Inflammatory Pathways and Therapeutic Innovations in Autism Spectrum Disorder: Exploring Neuroinflammatory Mechanisms and Targeted Treatments

  • By

  • Xinyu Zhang

  • Huiqin Xue

  • Chaoyang Zhu

  • Chen Ji

  • Yin Li

  • Wei Liu

  • May 20, 2026

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  • 1

    Autism spectrum disorder (ASD) is characterized by diverse symptoms and lacks reliable biomarkers for diagnosis and treatment.

  • 2

    Neuroinflammation is linked to ASD risk and symptom development, highlighting the need for targeted therapeutic interventions.

  • 3

    The Peripheral-to-Central Inflammatory Cascade-Amplification Model (PC-ICAM) outlines actionable nodes for ASD-related neuroinflammation.

  • 4

    Candidate interventions for ASD target various inflammatory pathways, including IL-6/IL-17 signaling and glial modulation.

  • 5

    A multi-node, mechanism-matched approach is essential for precision treatment of ASD, rather than relying on a single anti-inflammatory strategy.

Original Source(s)

Neuroinflammatory mechanisms and pharmacological advances in autism spectrum disorder: from inflammatory pathways to targeted interventions

  • by Xinyu Zhang, Huiqin Xue, Chaoyang Zhu, Chen Ji, Yin Li, Wei Liu

  • May 20, 2026

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