Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring - Takeaways - MDSpire
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Maternal Influenza During Pregnancy and Neuropsychiatric Outcomes in Children

  • By

  • Jaehyun Kong

  • Seohyun Hong

  • Hyesu Jo

  • Jaeyu Park

  • Kyeongeun Kim

  • Dongjin Yeo

  • Hyunjee Kim

  • Tae Hyeon Kim

  • José Francisco López-Gil

  • Hanseul Cho

  • Hyeon Seok Hwang

  • Selin Woo

  • Dong Keon Yon

  • October 8, 2026

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  • 1

    This binational mother-child cohort study examined associations between maternal influenza during pregnancy and offspring neuropsychiatric disorders in South Korea and Japan.

  • 2

    The discovery cohort included 3,012,992 participants in South Korea, and the replication cohort included 527,925 participants in Japan.

  • 3

    Maternal influenza exposure was defined as the first documented ICD-10 diagnosis of influenza during pregnancy.

  • 4

    The primary outcome was the child’s first postnatal diagnosis of a neuropsychiatric disorder, including severe disorders, OCD, ADHD, ASD, and intellectual disability.

  • 5

    The study addressed potential familial confounding, which prior sibling-comparison and negative-control analyses suggested could attenuate associations toward the null.

Original Source(s)

Maternal Influenza Infection During Pregnancy and Neuropsychiatric Disorders in Offspring

  • by Jaehyun Kong, Seohyun Hong, Hyesu Jo, Jaeyu Park, Kyeongeun Kim, Dongjin Yeo, Hyunjee Kim, Tae Hyeon Kim, José Francisco López-Gil, Hanseul Cho, Hyeon Seok Hwang, Selin Woo, Dong Keon Yon

  • October 8, 2026

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