C5orf46: a promising prognosis risk indicator with implication in the remodeling of KIRC and pan-cancer tumor microenvironments - Takeaways - MDSpire

C5orf46: a promising prognosis risk indicator with implication in the remodeling of KIRC and pan-cancer tumor microenvironments

  • By

  • Lei Miao

  • Fei Wang

  • Xuzhi Wang

  • Huijun Yang

  • Jiayao Li

  • Siying Liu

  • Ningning Shen

  • Zhiqing Yang

  • Lifang Gao

  • Wenxia Ma

  • Chen Wang

  • May 4, 2026

  • 0 min

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  • 1

    C5orf46 is a newly identified gene associated with tumor progression, particularly in kidney renal clear cell carcinoma (KIRC).

  • 2

    The study found that C5orf46 expression is significantly upregulated in various cancers, with the highest levels observed in KIRC.

  • 3

    Increased C5orf46 expression correlates with worse overall survival and shorter recurrence-free survival in cancer patients.

  • 4

    C5orf46 is linked to critical cancer traits such as angiogenesis, immune infiltration, and extracellular matrix degradation.

  • 5

    The findings suggest C5orf46 may serve as a prognostic biomarker and potential therapeutic target in cancer treatment.

Original Source(s)

C5orf46: a promising prognosis risk indicator with implication in the remodeling of KIRC and pan-cancer tumor microenvironments

  • by Lei Miao, Fei Wang, Xuzhi Wang, Huijun Yang, Jiayao Li, Siying Liu, Ningning Shen, Zhiqing Yang, Lifang Gao, Wenxia Ma, Chen Wang

  • May 4, 2026

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