C-type lectin receptor signaling in schistosomiasis

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Schistosomiasis, caused by Schistosoma parasites, affects over 250 million people globally and leads to significant morbidity.
2

C-type lectin receptors (CLRs) on immune cells interact with schistosome glycans, influencing immune responses during infection.
3

Key CLRs, such as mannose receptor and DC-SIGN, have distinct roles in regulating immune responses, including Th2 and Th17 pathways.
4

Severe immunopathology in schistosomiasis is characterized by granuloma formation around eggs, leading to liver fibrosis and portal hypertension.
5

Schistosome egg secretions contain immunomodulators that alter host immunity, with glycan profiles changing significantly during development.

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