High-throughput profiling of the T cell receptor delta CDR3 repertoire reveals species-specific patterns in cattle (Bos taurus) and water buffalo (Bubalus bubalis) - Takeaways - MDSpire

High-throughput profiling of the T cell receptor delta CDR3 repertoire reveals species-specific patterns in cattle (Bos taurus) and water buffalo (Bubalus bubalis)

  • By

  • Yueheng Zhang

  • Fengli Wu

  • Long Ma

  • Xinsheng Yao

  • Jun Li

  • May 28, 2026

  • 0 min

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  • 1

    This study analyzes the TRD CDR3 immune repertoire in cattle and water buffalo using high-throughput sequencing.

  • 2

    Cattle exhibit higher clonal evenness and overall diversity in their TRD CDR3 repertoire compared to water buffalo.

  • 3

    Both species show medium- to high-frequency clonotypes, but buffalo rely on fewer highly expanded clonotypes.

  • 4

    V(D)J gene usage analysis reveals species-specific preferences, with TRDJ gene usage being highly conserved between cattle and buffalo.

  • 5

    The findings provide insights into the unique patterns of γδ TCR diversity and potential immunological functions in these ruminants.

Original Source(s)

High-throughput profiling of the T cell receptor delta CDR3 repertoire reveals species-specific patterns in cattle (Bos taurus) and water buffalo (Bubalus bubalis)

  • by Yueheng Zhang, Fengli Wu, Long Ma, Xinsheng Yao, Jun Li

  • May 28, 2026

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