Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer - Takeaways - MDSpire

Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer

  • By

  • Cunen Wu

  • Yuanyuan Xu

  • Ming Zhao

  • Lihuiping Tao

  • Dayue Darrel Duan

  • Jun Qian

  • Shumin Zhao

  • Shenlin Liu

  • Jin-yong Zhou

  • June 10, 2026

  • 0 min

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  • 1

    Colorectal cancer (CRC) has high morbidity and mortality, with immunotherapy benefiting only a small subset of patients.

  • 2

    The study analyzed 27,414 cells to investigate NKT cell heterogeneity and interactions with Th1 cells in CRC.

  • 3

    Elevated NKT cell infiltration was associated with improved prognosis and enhanced sensitivity to immunotherapy.

  • 4

    The NTRG score quantified tumor-immune properties, linking high scores with worse overall survival but stronger immunotherapy response.

  • 5

    Validation confirmed differential NTRG expression between normal and cancerous tissues, aiding in understanding immunotherapy efficacy.

Original Source(s)

Integrated single-cell and spatial transcriptomics reveal immune landscape and NKT–Th1 signatures in colorectal cancer

  • by Cunen Wu, Yuanyuan Xu, Ming Zhao, Lihuiping Tao, Dayue Darrel Duan, Jun Qian, Shumin Zhao, Shenlin Liu, Jin-yong Zhou

  • June 10, 2026

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