Investigating the Duration of Empirical Antibiotic Treatment in Very Low Birth Weight Infants with Suspected Early-Onset Sepsis: A Retrospective Cohort Analysis of Contributing Factors - Takeaways - MDSpire

Investigating the Duration of Empirical Antibiotic Treatment in Very Low Birth Weight Infants with Suspected Early-Onset Sepsis: A Retrospective Cohort Analysis of Contributing Factors

  • By

  • Catalina Morales-Bentacourt

  • Maria Dolores Canales-Siguero

  • Marta Fernández-Gaitán

  • Adriana Montealegre-Pomar

  • Elena Bergon-Sedín

  • Concepción De Alba-Romero

  • Carmen Rosa Pallás Alonso

  • Maria Teresa Moral-Pumarega

  • April 29, 2026

  • 0 min

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  • 1

    The study analyzed empirical antibiotic treatment duration in very low birth weight infants with suspected early-onset sepsis and negative blood cultures.

  • 2

    Of 286 VLBW infants admitted, 161 received antibiotics, with a median exposure time of 45 hours before discontinuation.

  • 3

    Initiation of antibiotics during weekends was linked to an increase of 0.46 additional days of therapy.

  • 4

    Antibiotic discontinuation has become progressively earlier over the study period, yet exposure remains close to 48 hours.

  • 5

    The findings highlight the need for improved antibiotic stewardship to optimize treatment duration in high-risk VLBW infants.

Original Source(s)

Investigating the Duration of Empirical Antibiotic Treatment in Very Low Birth Weight Infants with Suspected Early-Onset Sepsis: A Retrospective Cohort Analysis of Contributing Factors

  • by Catalina Morales-Bentacourt, Maria Dolores Canales-Siguero, Marta Fernández-Gaitán, Adriana Montealegre-Pomar, Elena Bergon-Sedín, Concepción De Alba-Romero, Carmen Rosa Pallás Alonso, Maria Teresa Moral-Pumarega

  • April 29, 2026

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