From proteome-wide Mendelian randomization and multi-omics integration to functional validation: TGFB3 as a prioritized candidate in gastric adenocarcinoma - Takeaways - MDSpire

From proteome-wide Mendelian randomization and multi-omics integration to functional validation: TGFB3 as a prioritized candidate in gastric adenocarcinoma

  • By

  • Luming Zhao

  • Chenxi Mao

  • Yimeng Xu

  • Kangjie Zhou

  • Mingtong Liang

  • Yiqian Han

  • Jingzhou Zhang

  • Yidong Hong

  • Nan Hu

  • Fenglei Wu

  • July 6, 2026

  • 0 min

Share

  • 1

    The study utilized a proteome-wide Mendelian randomization framework to identify circulating proteins associated with gastric adenocarcinoma.

  • 2

    Twenty-nine circulating proteins were highlighted, with eight proteins, including TGFB3, prioritized for their central roles in the interaction network.

  • 3

    Single-cell and spatial transcriptomics revealed TGFB3 was enriched at tumor-stroma interfaces and linked to poor survival outcomes.

  • 4

    Proflavine hemisulfate was identified as a chemical probe that interacts with TGFB3, inhibiting its proliferation and survival signaling in gastric cancer cells.

  • 5

    The findings suggest TGFB3 as a potential target for therapeutic strategies in gastric adenocarcinoma, emphasizing the need for further investigation.

Original Source(s)

From proteome-wide Mendelian randomization and multi-omics integration to functional validation: TGFB3 as a prioritized candidate in gastric adenocarcinoma

  • by Luming Zhao, Chenxi Mao, Yimeng Xu, Kangjie Zhou, Mingtong Liang, Yiqian Han, Jingzhou Zhang, Yidong Hong, Nan Hu, Fenglei Wu

  • July 6, 2026

Related Content

Consolidative use of radiotherapy to block oligoprogression in patients with metastatic melanoma on Systemic Therapy (CURB-Melanoma) - a single arm, phase 2 clinical trial

Associations of static anatomical geometry with planned dosimetric endpoints in prostate radiotherapy: a multicenter study

Intraoperative technological advances and new frontiers in precision glioma surgery