Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage - Takeaways - MDSpire

Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage

  • By

  • Emily A Felton

  • Mary-Elizabeth Jobson

  • Nathanial J Torres

  • Rachel M Washburn

  • Ariana M Virgillio

  • Joshua Alvior

  • Eleonora Cella

  • Amorce Lima

  • Deanna Becker

  • Suzane Silbert

  • Taj Azarian

  • Kami Kim

  • Lindsey N Shaw

  • August 7, 2025

  • 0 min

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  • 1

    ST3390 is a novel MRSA variant from the CC5 lineage, characterized by its lack of staphyloxanthin pigment and unique genomic features.

  • 2

    Only 65 infections caused by ST3390 have been recorded globally, with a significant concentration of cases in Tampa.

  • 3

    ST3390 strains exhibit high cytotoxicity towards human neutrophils and demonstrate virulence in murine models of infection.

  • 4

    Genomic analysis revealed unique hybrid SCCmec types in ST3390, with most Tampa strains containing components from multiple SCCmec types.

  • 5

    This study enhances understanding of the clonal expansion of CC5 and the diversification of Staphylococcus aureus in patient populations.

Original Source(s)

Emergence of ST3390: A Novel Apigmented MRSA Clone From the CC5 Lineage

  • by Emily A Felton, Mary-Elizabeth Jobson, Nathanial J Torres, Rachel M Washburn, Ariana M Virgillio, Joshua Alvior, Eleonora Cella, Amorce Lima, Deanna Becker, Suzane Silbert, Taj Azarian, Kami Kim, Lindsey N Shaw

  • August 7, 2025

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