Serum HDAC3 as an Early Indicator for Predicting and Staging Acute Kidney Injury Associated with Sepsis: A Prospective Cohort Analysis - Takeaways - MDSpire

Serum HDAC3 as an Early Indicator for Predicting and Staging Acute Kidney Injury Associated with Sepsis: A Prospective Cohort Analysis

  • By

  • Wei-ying Liu

  • Min Chen

  • Dong-yu Chen

  • Xing Li

  • Bo Xi

  • Fang Chen

  • Yi-jun Deng

  • March 5, 2026

  • 0 min

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  • 1

    Over 40% of sepsis patients develop acute kidney injury (AKI), with mortality rates ranging from 50% to 70%.

  • 2

    Current AKI diagnosis relies on serum creatinine and urine output, which are often insufficient for early detection.

  • 3

    Histone deacetylase 3 (HDAC3) plays a critical role in kidney diseases and may serve as a potential biomarker for AKI.

  • 4

    This study aims to evaluate serum HDAC3 levels in sepsis patients to predict the onset of acute kidney injury within seven days.

  • 5

    The study enrolled patients diagnosed with sepsis and collected data to assess the predictive capacity of serum HDAC3.

Original Source(s)

Serum HDAC3 as an Early Indicator for Predicting and Staging Acute Kidney Injury Associated with Sepsis: A Prospective Cohort Analysis

  • by Wei-ying Liu, Min Chen, Dong-yu Chen, Xing Li, Bo Xi, Fang Chen, Yi-jun Deng

  • March 5, 2026

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