Evaluating the Prognostic Significance of the Coefficient of Variation in Metabolic Heterogeneity from Baseline 18F-FDG PET/CT in Newly Diagnosed Diffuse Large B-Cell Lymphoma

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Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, accounting for 30-40% of cases.
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Approximately 30-40% of DLBCL patients experience treatment failure with the standard R-CHOP regimen, leading to poor prognosis.
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Metabolic heterogeneity, assessed through 18F-FDG PET/CT, is crucial for predicting treatment response and patient prognosis in DLBCL.
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The coefficient of variation (COV) is a promising parameter for evaluating metabolic heterogeneity and its prognostic significance in DLBCL.
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This study aims to investigate the utility of COV from baseline 18F-FDG PET/CT in assessing progression-free and overall survival in DLBCL patients.

Bmc Cancer

by Siqi Hu, Zijie Shen, Ting Yang, Yujie Xie, Qiong Zou, Ju Jiao, Muhua Cheng, Yong Zhang
February 23, 2026

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