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1
A 3-year-and-5-month-old girl presented with an asymptomatic, enlarging red patch on the nasal dorsum, diagnosed as ALK-positive Spitz nevus.
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2
Histopathological examination revealed spindle cell proliferation in the dermis, with positive markers including S100, SOX10, and ALK.
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3
Spitz nevus is a benign melanocytic lesion commonly found in children, typically presenting as solitary lesions with low mitotic activity.
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4
Approximately 50% of Spitz nevi harbor kinase fusions like ALK, which are not predictive of malignant behavior but assist in differential diagnosis.
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5
The patient underwent complete surgical excision with no recurrence after over one year of follow-up, highlighting the need for close monitoring.
