Connective tissue diseases combined with chronic myelomonocytic leukemia and myelofibrosis: a case report and literature review

1

Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic disorder often associated with autoimmune diseases and secondary myelofibrosis.
2

A 52-year-old male patient with recurrent arthritis and fever was diagnosed with connective tissue disease (CTD) complicated by CMML and advanced myelofibrosis.
3

The patient underwent a dual-target treatment regimen of azacytidine and ruxolitinib, leading to significant improvement in symptoms and laboratory findings.
4

CMML patients frequently experience systemic inflammatory disorders, complicating diagnosis and treatment due to overlapping symptoms.
5

This case highlights the importance of recognizing the interplay between autoimmune diseases and hematologic malignancies for effective management.

1