Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation - Takeaways - MDSpire

Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation

  • By

  • Rui Zhang

  • Bin Yang

  • Na-Na Pan

  • Yi An

  • Qing Yu

  • May 20, 2026

  • 0 min

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  • 1

    The study involved 3,130 depression-free participants across CKM stages 0-4, assessing the link between CTI-related indices and incident depression.

  • 2

    CTI-CVAI showed the highest predictive value for depression risk, with an AUC of 0.705 and significant inverse associations with depression.

  • 3

    Higher baseline CTI-CVAI was linked to lower depression risk, particularly in individuals under 60 years of age.

  • 4

    The findings suggest that moderate cardiometabolic and nutritional reserves may support better mental health in older adults.

  • 5

    External validation confirmed the moderate discriminatory power of CTI-CVAI, reinforcing its potential as a candidate marker for depression risk.

Original Source(s)

Association of CTI and its obesity-related derivatives with incident depression among middle-aged and older adults across CKM stages 0-4: a nationwide prospective cohort study and external clinical validation

  • by Rui Zhang, Bin Yang, Na-Na Pan, Yi An, Qing Yu

  • May 20, 2026

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