Characterization of Adenovirus Types in Hospitalized US Pediatric Patients with Acute Respiratory Illness from 2016 to 2019

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Human adenovirus (HAdV) accounts for 5–13% of pediatric acute respiratory illness (ARI) cases globally.
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A multicenter study identified HAdV-C1, HAdV-C2, and HAdV-B3 as the most common types among 1843 HAdV-positive pediatric cases.
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Children infected with HAdV-B7 had significantly higher odds of severe outcomes compared to those with other HAdV types.
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Symptom presentations varied by HAdV type, with species B showing more non-respiratory symptoms despite high upper respiratory symptom frequency.
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The study highlights the need for targeted interventions based on specific HAdV types to improve prevention and treatment strategies.

Open Forum Infectious Diseases

by Tess Stopczynski, Varvara Probst, Adam Gailani, Justin Z Amarin, Olla Hamdan, Haya Hayek, Laura S Stewart, Herdi K Rahman, Rangaraj Selvarangan, Jennifer E Schuster, Christopher J Harrison, Mary E Moffatt, Marian G Michaels, John V Williams, Julie A Boom, Leila C Sahni, Vasanthi Avadhanula, Mary Allen Staat, Elizabeth P Schlaudecker, Christina Quigley, Geoffrey A Weinberg, Peter G Szilagyi, Janet A Englund, Eileen J Klein, Aaron T Curns, Heidi L Moline, Ariana P Toepfer, James D Chappell, Andrew J Spieker, Natasha B Halasa
November 12, 2025

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