Brain Imaging and Whole Blood Targeted Transcriptomic Analyses to Characterize Cerebral Infarctions in Children With Tuberculous Meningitis

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Cerebral infarctions occur in 40% to 70% of children with tuberculous meningitis, significantly impacting mortality and neurodevelopment.
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The study utilized brain imaging and transcriptomic analysis to investigate the relationship between inflammation and cerebral infarctions in pediatric TBM.
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Children with cerebral infarctions exhibited higher cerebrospinal fluid protein levels and lower glucose levels compared to those without infarctions.
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Matrix metalloproteinases and proinflammatory cytokines are implicated in the pathophysiology of TBM-associated cerebral infarctions.
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Adjunctive therapies like high-dose aspirin may reduce infarct incidence, but their effects on long-term outcomes remain under investigation.

The Journal Of Infectious Diseases

by Julie Huynh, Pieter M Pretorius, Wajanat Jan, Carolina Kachramanoglou, Nhat Hoang Thanh Le, Van La Ngoc, Hai Thanh Hoang, Ny Thi Hong Tran, Tram Ngoc Pham, Thu Anh Dang Do, Dung Thi Mong Vu, Trinh Thi Bich Tram, Do Dinh Vinh, Tung Huu Trinh, Nguyen Dinh Qui, Minh Ha Thi Dang, Elena Frangou, Sierra Santana, Caitlin Muller, Suzanne T Anderson, Diana M Gibb, Nhung Thi Hong Nguyen, Nguyen Thuy Thuong Thuong, Guy Thwaites, on behalf of the SURE Trial Team
August 2, 2025

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