Thyroid autoimmunity is associated with fertilization impairment and follicular fluid exosomal miRNA alterations in euthyroid women undergoing IVF-ET - Takeaways - MDSpire

Thyroid autoimmunity is associated with fertilization impairment and follicular fluid exosomal miRNA alterations in euthyroid women undergoing IVF-ET

  • By

  • Lanping Zhong

  • Yuting Luo

  • Jiani Zhu

  • Xin Li

  • Yuhong Niu

  • Ji-Gan Wang

  • Xiaomin Kang

  • July 10, 2026

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  • 1

    Thyroid autoimmunity (TAI) negatively impacts fertilization outcomes in euthyroid women undergoing IVF-ET.

  • 2

    Among 4,332 infertile women studied, 565 were TAI-positive, showing significantly lower fertilization rates.

  • 3

    Exosomal miRNA sequencing identified 70 differentially expressed miRNAs in follicular fluid related to TAI.

  • 4

    Four key miRNAs were identified: hsa-miR-6799-3p, hsa-miR-6836-3p, hsa-miR-4449, and hsa-miR-3162-5p.

  • 5

    Functional enrichment analysis suggests these miRNAs may influence TAI-related reproductive impairment pathways.

Original Source(s)

Thyroid autoimmunity is associated with fertilization impairment and follicular fluid exosomal miRNA alterations in euthyroid women undergoing IVF-ET

  • by Lanping Zhong, Yuting Luo, Jiani Zhu, Xin Li, Yuhong Niu, Ji-Gan Wang, Xiaomin Kang

  • July 10, 2026

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