FLASH Radiotherapy Maintains Systemic and Tissue Balance While Effectively Targeting Tumors

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FLASH-RT delivers radiation at ultra-high dose rates, significantly reducing normal tissue toxicity while maintaining tumor control.
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Melanoma, a radio-resistant cancer, poses challenges for treatment, highlighting the need for innovative radiotherapy approaches like FLASH-RT.
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Preclinical studies indicate FLASH-RT spares normal tissues across various organs, suggesting its broad translational potential.
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The mechanisms behind the FLASH effect remain unclear, with hypotheses including oxygen depletion and altered DNA damage responses.
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This study compares FLASH-RT and CONV-RT in a melanoma model, focusing on long-term systemic effects and late normal tissue responses.

Bmc Medicine

by Giulia Furini, Eduarda Mota da Silva, Alice Usai, Gaia Scabia, Claudia Kusmic, Francesco Faita, Andrea Cavalieri, Mariagrazia Celentano, Mario Costa, Filippo Rossi, Giulia Asero, Roberta Di Pietro, Emanuela Guerra, Stefano Lattanzio, Tonia Luca, Sergio Castorina, Roberto Cusano, Riccardo Berutti, Jessica Milia, Simone Capaccioli, Alessandra Gonnelli, Noemi Giannini, Fabiola Paiar, Saverio Cinti, Fabio Di Martino, Margherita Maffei
February 26, 2026

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