Cytokine delivery and targeting strategies in pet dogs with cancer: a comparative immuno-oncology approach

1

Cytokine therapies face challenges due to systemic absorption causing immune-related toxicity, limiting therapeutic concentrations in tumors.
2

Engineering cytokines with tunable biodistribution properties offers new opportunities for cytokine-based immunotherapies in clinical settings.
3

Pet dogs with spontaneous cancers provide a valuable model for studying cytokine delivery strategies and their effects on tumor immunobiology.
4

Comparative oncology leverages similarities between canine and human cancers to inform drug development and evaluate novel cancer therapeutics.
5

Cytokines have shown potential in treating human cancers, but their clinical translation is limited by systemic toxicity and adverse events.

1