Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis

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Endometriosis affects approximately 10% of women of reproductive age, causing chronic pelvic pain and significantly reducing quality of life.
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Hormonal treatments, including COCs and progestins, effectively reduce pelvic pain and menstrual irregularities in endometriosis patients.
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Dienogest has been identified as particularly effective for alleviating dysmenorrhea, with a standardized mean difference of -0.58.
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Relugolix combined therapy significantly reduces endometriosis-related pain, achieving a standardized mean difference of -0.72.
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Adjunctive therapies like antioxidants and digital therapeutics also provide additional pain relief and improve quality of life for patients.

Frontiers In Endocrinology

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