Infant CD4 T-Cell Response to SARS-CoV-2 mRNA Vaccination Is Restricted in Cytokine Production and Modified by Vaccine Manufacturer - Takeaways - MDSpire

Infant CD4 T-Cell Response to SARS-CoV-2 mRNA Vaccination Is Restricted in Cytokine Production and Modified by Vaccine Manufacturer

  • By

  • M Quinn Peters

  • Amber L Young

  • Jennifer E Stolarczuk

  • Madeline Glad

  • Erik Layton

  • Jennifer K Logue

  • Nana K Minkah

  • Helen Y Chu

  • Janet A Englund

  • D Noah Sather

  • Chetan Seshadri

  • Alisa Kachikis

  • Whitney E Harrington

  • September 29, 2025

  • 0 min

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  • 1

    Infants exhibit limited CD4 T-cell cytokine responses post-SARS-CoV-2 mRNA vaccination compared to adults.

  • 2

    Vaccination increased IL-2 and TNF-α production in infants, but IFN-γ induction was muted.

  • 3

    CD4 T-cell responses were more pronounced in infants receiving the mRNA-1273 vaccine compared to BNT162b.

  • 4

    Spike-specific IgG titers were similar between infants and adults, despite differences in T-cell responses.

  • 5

    The study highlights the need for further investigation into T-cell responses in infant vaccination.

Original Source(s)

Infant CD4 T-Cell Response to SARS-CoV-2 mRNA Vaccination Is Restricted in Cytokine Production and Modified by Vaccine Manufacturer

  • by M Quinn Peters, Amber L Young, Jennifer E Stolarczuk, Madeline Glad, Erik Layton, Jennifer K Logue, Nana K Minkah, Helen Y Chu, Janet A Englund, D Noah Sather, Chetan Seshadri, Alisa Kachikis, Whitney E Harrington

  • September 29, 2025

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