Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib - Takeaways - MDSpire

Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib

  • By

  • Jean-Claude Tardif

  • Marc A Pfeffer

  • Simon Kouz

  • Wolfgang Koenig

  • Aldo P Maggioni

  • John J V McMurray

  • David D Waters

  • J Wouter Jukema

  • Harvey D White

  • Therese Heinonen

  • David Kallend

  • Fouzia Laghrissi-Thode

  • Valtteri Muroke

  • Annik Fortier

  • Marie-Claude Guertin

  • Marie-Pierre Dubé

  • for the dal-GenE Investigators

  • October 14, 2025

  • 0 min

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  • 1

    Acute coronary syndrome survivors face a heightened risk of future myocardial infarction, necessitating effective prediction models.

  • 2

    A prediction index developed from the dal-Outcomes trial identified 18 significant risk markers for myocardial infarction.

  • 3

    Dalcetrapib significantly reduced the risk of myocardial infarction by 23% in patients with the AA genotype at rs1967309.

  • 4

    Key predictors of future myocardial infarction include prior coronary events, LDL-cholesterol, blood pressure, and smoking.

  • 5

    The dal-GenE trial aims to confirm the pharmacogenetic hypothesis regarding dalcetrapib's efficacy in specific genetic populations.

Original Source(s)

Future myocardial infarction after an acute coronary syndrome and pharmacogenetic response to dalcetrapib

  • by Jean-Claude Tardif, Marc A Pfeffer, Simon Kouz, Wolfgang Koenig, Aldo P Maggioni, John J V McMurray, David D Waters, J Wouter Jukema, Harvey D White, Therese Heinonen, David Kallend, Fouzia Laghrissi-Thode, Valtteri Muroke, Annik Fortier, Marie-Claude Guertin, Marie-Pierre Dubé, for the dal-GenE Investigators

  • October 14, 2025

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