Matrix metalloproteinase expression in basal cell carcinoma, squamous carcinoma, and melanoma: diagnostic and prognostic potential - Takeaways - MDSpire

Matrix metalloproteinase expression in basal cell carcinoma, squamous carcinoma, and melanoma: diagnostic and prognostic potential

  • By

  • Giovanni Francesco Spatola

  • Alessandro Pitruzzella

  • Antonino Gioacchino Listro

  • Carla Valenti

  • Mariaelena Scalisi

  • Federica Milia

  • Paolo Listro

  • Flavia Zingales

  • Giulio Maria Ferranti

  • Marta Listro

  • Beatrice Belmonte

  • Domiziana Picone

  • Giorgia Intili

  • Maria Laura Uzzo

  • May 4, 2026

  • 0 min

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  • 1

    Matrix metalloproteinases (MMP-3, MMP-9, MMP-14) play crucial roles in tumor invasion and angiogenesis in skin cancers.

  • 2

    Basal cell carcinoma (BCC) shows strong expression of MMP-3 and MMP-14, indicating local proliferation and stromal remodeling.

  • 3

    Squamous cell carcinoma (SCC) exhibits weak MMP-14 expression, with MMP-3 and MMP-9 completely absent, suggesting low metastatic potential.

  • 4

    Melanoma demonstrates high expression of all three MMPs, correlating with aggressive invasion and angiogenesis.

  • 5

    MMP-3 and MMP-14 may serve as valuable diagnostic and prognostic biomarkers for skin cancer management.

Original Source(s)

Matrix metalloproteinase expression in basal cell carcinoma, squamous carcinoma, and melanoma: diagnostic and prognostic potential

  • by Giovanni Francesco Spatola, Alessandro Pitruzzella, Antonino Gioacchino Listro, Carla Valenti, Mariaelena Scalisi, Federica Milia, Paolo Listro, Flavia Zingales, Giulio Maria Ferranti, Marta Listro, Beatrice Belmonte, Domiziana Picone, Giorgia Intili, Maria Laura Uzzo

  • May 4, 2026

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