Bacterial Pseudaminic Acid Emerges as an Immune Target
Glycoproteomic mapping reveals pseudaminic acid as a shared feature across pathogenic bacteria
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Pseudaminic acid, a bacterial sugar, may help expose drug-resistant pathogens to the immune system.
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Monoclonal antibodies targeting pseudaminic acid can recognize multiple pathogenic species and eliminate infections in mice.
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Researchers developed synthetic glycopeptides to create pan-specific antibodies that bind various forms of pseudaminic acid.
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The study established a glycoproteomic workflow to map pseudaminic acid in key pathogens like Helicobacter pylori.
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The findings suggest potential for new passive immunotherapies against multidrug-resistant Acinetobacter baumannii.
