Case Report: dynamic monocyte reprogramming during ALSS therapy in type B HBV-ACLF revealed by single-cell transcriptomics - Takeaways - MDSpire

Case Report: dynamic monocyte reprogramming during ALSS therapy in type B HBV-ACLF revealed by single-cell transcriptomics

  • By

  • Jiale Xie

  • Jiahua Liu

  • Feiyu Wang

  • Dongxuan Zhang

  • Yuyao Tian

  • Júlio Ken Matsubara

  • Jingxiang Zhang

  • Jie Yin

  • Zian Chen

  • Huimin Liu

  • Xiaoshuang Xu

  • Xin Wang

  • Guifen Liu

  • Jianhua Wang

  • Yansheng Jia

  • Lili Chang

  • Yu Guo

  • Wei Qi

  • Yan Wang

  • May 26, 2026

  • 0 min

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  • 1

    HBV-ACLF is marked by systemic inflammation and immune dysregulation, with monocytes significantly influencing its progression.

  • 2

    Single-cell RNA sequencing revealed dynamic reprogramming of monocytes during ALSS treatment in a patient with type B HBV-ACLF.

  • 3

    A distinct inflammatory monocyte subpopulation, Mono4, was identified, showing increased mitochondrial gene expression and pro-inflammatory factors.

  • 4

    ALSS treatment led to a reduction in the Mono4 subpopulation and its associated pro-inflammatory secretory profile.

  • 5

    The study highlights the potential role of Mono4 in systemic hyperinflammation during HBV-ACLF and the therapeutic impact of ALSS.

Original Source(s)

Case Report: dynamic monocyte reprogramming during ALSS therapy in type B HBV-ACLF revealed by single-cell transcriptomics

  • by Jiale Xie, Jiahua Liu, Feiyu Wang, Dongxuan Zhang, Yuyao Tian, Júlio Ken Matsubara, Jingxiang Zhang, Jie Yin, Zian Chen, Huimin Liu, Xiaoshuang Xu, Xin Wang, Guifen Liu, Jianhua Wang, Yansheng Jia, Lili Chang, Yu Guo, Wei Qi, Yan Wang

  • May 26, 2026

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