Dual-Site Theta Burst Stimulation May Reduce Suicidal Ideation
Four-day treatment targeting the prefrontal cortex and cerebellum produced larger reductions in suicidal ideation scores than prefrontal stimulation alone in adolescents with major depressive disorder.
Dual-site accelerated intermittent theta burst stimulation may reduce suicidal ideation in adolescents with major depressive disorder compared to single-site stimulation.
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The randomized clinical trial involved 59 patients aged 12 to 18 years, diagnosed with major depressive disorder and exhibiting significant suicidal ideation.
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Mean Beck Scale for Suicide Ideation scores decreased more in the dual-site group, from 22.6 to 8.2, compared to the single-site group's decrease from 23.3 to 13.9.
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Response rates for suicidal ideation were 59% in the dual-site group and 37% in the single-site group, with remission rates of 48% and 30%, respectively.
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Common adverse events included pain at stimulation sites and dizziness, which resolved within approximately 30 minutes after treatment.
