Gut-brain axis disruption, intestinal barrier damage, and systemic inflammation as predictors of POCD after cholecystectomy: a nested case-control study - Takeaways - MDSpire

Gut-brain axis disruption, intestinal barrier damage, and systemic inflammation as predictors of POCD after cholecystectomy: a nested case-control study

  • By

  • Yanlong Fu

  • Qiang Wei

  • Huiru Chen

  • Xiaoyun Wu

  • Menghan Li

  • Wenxin Shi

  • June 19, 2026

  • 0 min

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  • 1

    Postoperative cognitive dysfunction (POCD) occurs in 6.7% of patients following cholecystectomy, impacting memory and cognitive function.

  • 2

    Dysregulated gut-brain axis biomarkers and sustained postoperative inflammation are observed in patients with POCD.

  • 3

    Postoperative levels of LBP and IL-6 are identified as independent risk factors for developing POCD.

  • 4

    A higher preoperative MMSE score serves as a protective factor against the risk of POCD.

  • 5

    The study highlights the association between intestinal barrier dysfunction, systemic inflammation, and POCD following cholecystectomy.

Original Source(s)

Gut-brain axis disruption, intestinal barrier damage, and systemic inflammation as predictors of POCD after cholecystectomy: a nested case-control study

  • by Yanlong Fu, Qiang Wei, Huiru Chen, Xiaoyun Wu, Menghan Li, Wenxin Shi

  • June 19, 2026

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