Serum hepcidin is associated with retinopathy of prematurity and modulates oxidative stress and angiogenic responses in retinal microvascular endothelial cells - Takeaways - MDSpire

Serum hepcidin is associated with retinopathy of prematurity and modulates oxidative stress and angiogenic responses in retinal microvascular endothelial cells

  • By

  • Hui Yang

  • Huiyun Chen

  • Fang Cheng

  • Jingbo Jiang

  • June 8, 2026

  • 0 min

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  • 1

    Retinopathy of prematurity (ROP) is a significant cause of blindness in preterm infants, linked to impaired vascular development and hypoxia.

  • 2

    Infants with ROP exhibited lower gestational age and birth weight compared to non-ROP controls, indicating a correlation with disease severity.

  • 3

    Serum hepcidin levels were numerically lower in ROP infants, suggesting a potential role in the pathophysiology of the condition.

  • 4

    In vitro studies showed that hepcidin reduced oxidative stress and angiogenic activity in retinal microvascular endothelial cells under hypoxia.

  • 5

    Hepcidin may serve as a promising biomarker and therapeutic target for ROP, warranting further research into its clinical applications.

Original Source(s)

Serum hepcidin is associated with retinopathy of prematurity and modulates oxidative stress and angiogenic responses in retinal microvascular endothelial cells

  • by Hui Yang, Huiyun Chen, Fang Cheng, Jingbo Jiang

  • June 8, 2026

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