Interleukin−1 receptor antagonist and heat shock protein 90alfa are independently associated with fatigue and general health in euthyroid Hashimoto’s thyroiditis - Takeaways - MDSpire

Interleukin−1 receptor antagonist and heat shock protein 90alfa are independently associated with fatigue and general health in euthyroid Hashimoto’s thyroiditis

  • By

  • Roald Omdal

  • Tore Grimstad

  • Grete Jonsson

  • Jan Terje Kvaløy

  • Charlotte Gibbs

  • Laurens C. Reitsma

  • Tomm Bernklev

  • Geir Hoff

  • July 2, 2026

  • 0 min

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  • 1

    Hashimoto’s thyroiditis can cause significant fatigue and impaired health-related quality of life in euthyroid patients.

  • 2

    Interleukin-1 receptor antagonist (IL-1Ra) is independently associated with poorer general health and increased fatigue.

  • 3

    Heat shock protein 90α (HSP90α) shows an inverse association with fatigue, suggesting a potentially protective role.

  • 4

    IL-6, TNF-α, and anti-TPO were not significantly associated with patient-reported outcomes in the study.

  • 5

    The study highlights the role of immune-mediated mechanisms in symptom generation beyond thyroid hormone deficiency.

Original Source(s)

Interleukin−1 receptor antagonist and heat shock protein 90alfa are independently associated with fatigue and general health in euthyroid Hashimoto’s thyroiditis

  • by Roald Omdal, Tore Grimstad, Grete Jonsson, Jan Terje Kvaløy, Charlotte Gibbs, Laurens C. Reitsma, Tomm Bernklev, Geir Hoff

  • July 2, 2026

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