Immunogenicity and safety of primary three-dose series with diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed in 3 months infants - Takeaways - MDSpire

Immunogenicity and safety of primary three-dose series with diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed in 3 months infants

  • By

  • Wei Zhang

  • Chen Wei

  • Haitao Huang

  • Xue Wang

  • Zhiqiang Xie

  • Yan Wu

  • Feiyu Wang

  • Lili Huang

  • Xuewen Wang

  • Xiuwen Sui

  • Peng Wan

  • Zhe Chao

  • Jinbo Gou

  • Bozhi Shi

  • Jia Liu

  • Tao Zhu

  • Liyong Yuan

  • Yanxia Wang

  • July 7, 2026

  • 0 min

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  • 1

    The study evaluated the safety and immunogenicity of a novel DTcP vaccine compared to co-purified DTaP and DTaP-IPV-Hib vaccines in infants.

  • 2

    A total of 1,140 infants received a three-dose primary series of the vaccines at 3, 4, and 5 months of age.

  • 3

    DTcP and co-purified DTaP vaccines had lower overall adverse reactions compared to the DTaP-IPV-Hib vaccine.

  • 4

    DTcP demonstrated superior immunogenicity with a 98.16% seroconversion rate for anti-FHA, compared to 14.29% for co-purified DTaP.

  • 5

    The study supports the potential transition from co-purified to component-based acellular pertussis vaccines in China's immunization strategy.

Original Source(s)

Immunogenicity and safety of primary three-dose series with diphtheria, tetanus and pertussis (acellular, three components) combined vaccine, adsorbed in 3 months infants

  • by Wei Zhang, Chen Wei, Haitao Huang, Xue Wang, Zhiqiang Xie, Yan Wu, Feiyu Wang, Lili Huang, Xuewen Wang, Xiuwen Sui, Peng Wan, Zhe Chao, Jinbo Gou, Bozhi Shi, Jia Liu, Tao Zhu, Liyong Yuan, Yanxia Wang

  • July 7, 2026

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