Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment - Takeaways - MDSpire
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Exploring the Relationship Between Attention-Deficit/Hyperactivity Disorder and Chronic Pain: A Comprehensive Review of Epidemiology, Clinical Features, Mechanisms, and Treatment Approaches

  • By

  • Satoshi Kasahara

  • Shuntaro Aoki

  • Miwako Takahashi

  • Ryo Motoya

  • Takuma Sanpei

  • Taito Morita

  • Yusaku Fukada

  • Shin-Ichi Niwa

  • July 13, 2026

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  • 1

    This scoping review examines the association between ADHD and chronic pain, synthesizing evidence across multiple disciplines.

  • 2

    Fifty studies were included, revealing significant associations between ADHD symptoms and chronic pain in various populations.

  • 3

    Higher ADHD symptom burden correlates with increased pain severity and functional impairment in individuals with chronic pain.

  • 4

    Proposed mechanisms involve dopaminergic and noradrenergic dysfunction affecting pain modulation and sensory processing.

  • 5

    Case reports suggest improvements in pain outcomes with ADHD-targeted pharmacotherapy, but controlled trials are limited.

Original Source(s)

Attention-deficit/hyperactivity disorder and chronic pain: a scoping review of epidemiology, clinical phenotypes, mechanisms, and treatment

  • by Satoshi Kasahara, Shuntaro Aoki, Miwako Takahashi, Ryo Motoya, Takuma Sanpei, Taito Morita, Yusaku Fukada, Shin-Ichi Niwa

  • July 13, 2026

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