Case report: A rare case of retroperitoneal mixed type unicentric Castleman disease - Takeaways - MDSpire

Case report: A rare case of retroperitoneal mixed type unicentric Castleman disease

  • By

  • Jiajie Zhang

  • Jian Zhang

  • Jinhao Liu

  • Panying Zhang

  • Shoubin Li

  • May 1, 2026

  • 0 min

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  • 1

    A 52-year-old woman presented with increased urination and was diagnosed with retroperitoneal mixed type unicentric Castleman disease.

  • 2

    The patient underwent laparoscopic resection of the retroperitoneal tumor, which was confirmed as mixed type unicentric Castleman disease postoperatively.

  • 3

    Castleman disease is a rare benign lymphoproliferative disorder, with unicentric cases often misdiagnosed due to nonspecific symptoms.

  • 4

    Histopathological examination revealed reactive hyperplasia of lymphoid tissue, highlighting the unique features of mixed type unicentric Castleman disease.

  • 5

    Increased awareness and thorough investigation are essential for the recognition and management of retroperitoneal mixed type unicentric Castleman disease.

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