CCR1-mediated monocyte chemotaxis in the immunopathology of primary Sjögren’s syndrome: multi-omics integration analysis and computational target prioritization implicating Polygonatum odoratum - Takeaways - MDSpire

Investigating CCR1's Role in Monocyte Migration within the Immunopathology of Primary Sjögren’s Syndrome: A Multi-Omics Approach and Computational Analysis Highlighting Polygonatum odoratum as a Potential Therapeutic Target

  • By

  • Jianbin Li

  • Yuzhen Gesang

  • Ning Tan

  • Renhe Li

  • Wei Liu

  • July 20, 2026

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  • 1

    Primary Sjögren’s syndrome (pSS) is a chronic autoimmune disease with no specific treatment, affecting primarily women aged 40-60.

  • 2

    CCR1 was identified as a candidate target in pSS, being significantly upregulated in patients and correlated with serum IgG levels.

  • 3

    Single-cell analysis revealed that CCR1 is predominantly expressed in classical monocytes, which are expanded in pSS patients.

  • 4

    Moupinamide from Polygonatum odoratum showed predicted binding affinity to CCR1, suggesting a potential therapeutic role.

  • 5

    The study utilized multi-omics approaches to explore CCR1's role in pSS immunopathology and its association with monocyte recruitment.

Original Source(s)

CCR1-mediated monocyte chemotaxis in the immunopathology of primary Sjögren’s syndrome: multi-omics integration analysis and computational target prioritization implicating Polygonatum odoratum

  • by Jianbin Li, Yuzhen Gesang, Ning Tan, Renhe Li, Wei Liu

  • July 20, 2026

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