Identification of ferroptosis hub gene cDKN1A relating to immune microenvironment in rheumatoid arthritis via bioinformatic analysis and experimental verification - Takeaways - MDSpire

Identification of ferroptosis hub gene cDKN1A relating to immune microenvironment in rheumatoid arthritis via bioinformatic analysis and experimental verification

  • By

  • Fuling Chen

  • Fuqiang Tan

  • Wen Zou

  • Jingkun Liu

  • Zhengxue Quan

  • July 9, 2026

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  • 1

    Rheumatoid arthritis (RA) affects about 1% of the global population and is characterized by chronic inflammation and joint damage.

  • 2

    Approximately 40% of RA patients do not respond adequately to disease-modifying anti-rheumatic drugs, leading to persistent symptoms.

  • 3

    Ferroptosis, a regulated form of cell death, is linked to the progression of autoimmune and inflammatory diseases, including RA.

  • 4

    The study utilized bioinformatics and experimental validation to identify ferroptosis-related biomarkers associated with RA.

  • 5

    Differential expression analysis and machine learning techniques were employed to identify key genes and their relationship with immune cells.

Original Source(s)

Identification of ferroptosis hub gene cDKN1A relating to immune microenvironment in rheumatoid arthritis via bioinformatic analysis and experimental verification

  • by Fuling Chen, Fuqiang Tan, Wen Zou, Jingkun Liu, Zhengxue Quan

  • July 9, 2026

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