Association of high-density lipoprotein cholesterol with the top 10 causes of death - Takeaways - MDSpire

Association of high-density lipoprotein cholesterol with the top 10 causes of death

  • By

  • Shanshan Shi

  • Zhangyu Lin

  • Yanjun Song

  • Zixiang Ye

  • Chenxi Song

  • Kefei Dou

  • November 24, 2025

  • 0 min

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  • 1

    This study analyzed the relationship between high-density lipoprotein cholesterol (HDL-C) levels and mortality from the top 10 global causes of death.

  • 2

    U-shaped associations were found between HDL-C levels and death risk from ischemic heart disease, infections, lung cancer, diabetes, and kidney disease.

  • 3

    Optimal HDL-C levels for minimizing death risk were identified as 58–74 mg/dL for females and 50–60 mg/dL for males.

  • 4

    Chronic obstructive pulmonary disease and liver disease showed J-shaped curves, indicating increased risk with high HDL-C levels.

  • 5

    The study highlights the importance of evaluating HDL functionality rather than just quantity in assessing health risks.

Original Source(s)

Association of high-density lipoprotein cholesterol with the top 10 causes of death

  • by Shanshan Shi, Zhangyu Lin, Yanjun Song, Zixiang Ye, Chenxi Song, Kefei Dou

  • November 24, 2025

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