OI Therapy Raised BMD, Not Fracture Benefit - Takeaways - MDSpire
Coming Soon: Introducing MDSpire News. Learn more
Conexiant’s news site is now MDSpire News. Learn more

OI Therapy Raised BMD, Not Fracture Benefit

Teriparatide followed by zoledronic acid increased bone mineral density but did not reduce fracture risk compared with standard care in adults with osteogenesis imperfecta.

  • By

  • Andrea Surnit

  • June 5, 2026

  • 7 min

Share

  • 1

    The TOPaZ trial found no significant reduction in fractures for adults with osteogenesis imperfecta treated with teriparatide and zoledronic acid.

  • 2

    Bone mineral density increased in the intervention group, but this did not correlate with a decrease in imaging-confirmed fractures.

  • 3

    Adherence to treatment was high in the intervention group at 98.3%, compared to 44.5% in the standard-care group.

  • 4

    Secondary analyses showed no statistically significant fracture benefit from teriparatide followed by zoledronic acid.

  • 5

    The study's limitations included fewer primary outcome fractures than expected, affecting the ability to detect treatment effects.

Original Source(s)

OI Therapy Raised BMD, Not Fracture Benefit

  • by Andrea Surnit

  • June 5, 2026

Related Content

Beyond the Foot and Ankle: How Atlantic Health's Wayne Pavilion Is Simplifying Musculoskeletal Care

A patient may present with a persistent ankle sprain, chronic heel pain, or an acute fracture, but the underlying story is often more complex. Gait abnormalities can contribute to knee, hip, and back pain. Sports injuries may require advanced imaging, physical therapy, and surgical evaluation. Fractures frequently demand coordinated care across multiple services before treatment can begin.

  • by

  • June 30, 2026

  • 7 min
Medical Oddities: Natural Doesn't Always Mean Safe

From the gym to the kitchen to romance, these studies challenge everyday assumptions.

Validity and prognostic value of a novel intraoperative assessment tool for reduction in trimalleolar fractures: the SGSC checklist approach