Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance - Takeaways - MDSpire

Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance

  • By

  • Cecilia Ángel-Reimúndez

  • Manuel F. Ruibal-Caballero

  • Virginia Leiro-Fernández

  • Milenis Salgado-Arteta

  • Lucas C. González-Matías

  • Alberto Fernández-Villar

  • Federico Mallo

  • May 25, 2026

  • 0 min

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  • 1

    The review focuses on molecular biomarkers related to pulmonary fibrosis in bronchoalveolar lavage fluid and saliva.

  • 2

    Key biomarkers discussed include type I collagen, hydroxyproline, fibronectin, elastin, KL-6, and matrix metalloproteinases.

  • 3

    The review highlights the potential for non-invasive monitoring strategies through the alveolus-saliva pathophysiological axis.

  • 4

    Current studies lack simultaneous analysis of BALF and saliva, along with standardized protocols for sampling and normalization.

  • 5

    The review identifies opportunities for developing BALF-saliva multimarker panels for diagnostic and prognostic use in fibrotic lung diseases.

Original Source(s)

Biomarkers of pulmonary fibrosis in bronchoalveolar lavage fluid and saliva. Study methods and pathophysiological significance

  • by Cecilia Ángel-Reimúndez, Manuel F. Ruibal-Caballero, Virginia Leiro-Fernández, Milenis Salgado-Arteta, Lucas C. González-Matías, Alberto Fernández-Villar, Federico Mallo

  • May 25, 2026

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