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1
Eosinophils are ancient immune cells, tracing back 100 million years, and play diverse roles in health and disease beyond traditional Th2 responses.
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2
Historically, eosinophils have been linked to allergic asthma and helminth infections, characterized as potent cytotoxic effector cells.
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3
Eosinophils exhibit dual roles in cancer, acting as both anti-tumorigenic and pro-tumorigenic mediators depending on the tumor microenvironment.
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4
Emerging functions of eosinophils include tissue repair, regeneration, and involvement in various disorders such as obesity and SARS-CoV-2.
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5
Eosinophils develop from hematopoietic stem cells in the bone marrow, regulated by cytokines like IL-5, and migrate to specific tissues during inflammation.
