Potential value of vitamin D as adjunctive therapy in osteoarticular tuberculosis: a comprehensive review

1

Osteoarticular tuberculosis (OATB) accounts for 10% to 15% of extrapulmonary tuberculosis (EPTB) cases and can lead to severe complications.
2

Standard chemotherapy for tuberculosis effectively controls Mycobacterium tuberculosis but has limited effectiveness in reversing bone destruction.
3

Vitamin D plays a crucial role in immune regulation and bone metabolism, with its active form influencing gene transcription through the vitamin D receptor.
4

Epidemiological studies indicate a bidirectional relationship between vitamin D deficiency and tuberculosis risk, complicating causal interpretations.
5

Current research on vitamin D's role in tuberculosis primarily focuses on pulmonary forms, with limited studies on OATB-specific immune mechanisms.

Infection

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