Comparing intraoperative radiotherapy (IORT) and hypofractionated stereotactic radiotherapy (HSRT) after brain metastasis surgery: impact on oncological outcome and radionecrosis - Takeaways - MDSpire

Comparing intraoperative radiotherapy (IORT) and hypofractionated stereotactic radiotherapy (HSRT) after brain metastasis surgery: impact on oncological outcome and radionecrosis

  • By

  • Maria Neu

  • Ehab Shiban

  • Philipp Krauss

  • Björn Sommer

  • Zoha Roushan

  • Susanne Gutser

  • Christoph J. Maurer

  • Tilman Janzen

  • Georg Stüben

  • Klaus-Henning Kahl

  • August 13, 2025

  • 0 min

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  • 1

    Surgical resection of brain metastases is effective but has high local recurrence rates without adjuvant therapy.

  • 2

    IORT allows immediate radiation delivery during surgery, potentially reducing delays and uncertainties in treatment.

  • 3

    This study compares IORT and HSRT regarding oncological outcomes and treatment-related toxicity in brain metastasis management.

  • 4

    The one-year incidence of radionecrosis was significantly lower in the IORT group compared to the HSRT group.

  • 5

    Median operation time was longer for IORT, but it provided a more immediate treatment option post-surgery.

Original Source(s)

Comparing intraoperative radiotherapy (IORT) and hypofractionated stereotactic radiotherapy (HSRT) after brain metastasis surgery: impact on oncological outcome and radionecrosis

  • by Maria Neu, Ehab Shiban, Philipp Krauss, Björn Sommer, Zoha Roushan, Susanne Gutser, Christoph J. Maurer, Tilman Janzen, Georg Stüben, Klaus-Henning Kahl

  • August 13, 2025

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