Case report: Helical tomotherapy-based whole lung irradiation with simultaneous integrated boost for pulmonary metastatic Ewing’s sarcoma: a case series report and feasibility analysis - Takeaways - MDSpire

Case report: Helical tomotherapy-based whole lung irradiation with simultaneous integrated boost for pulmonary metastatic Ewing’s sarcoma: a case series report and feasibility analysis

  • By

  • YuanYou Yang

  • Lu Xie

  • Jie Xu

  • Xin Sun

  • Gang Ren

  • May 20, 2026

  • 0 min

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  • 1

    Helical Tomotherapy (HT) enables effective whole-lung irradiation (WLI) with simultaneous integrated boost (SIB) for pulmonary metastatic Ewing's sarcoma.

  • 2

    The case series included five patients aged 15-36 years, with an overall response rate of 86.7% after HT-based WLI with SIB.

  • 3

    Median lung/pleural progression-free survival was 5.5 months, with four patients surviving and one patient dying from extrapulmonary progression.

  • 4

    Acute toxicity was manageable, with one case of grade 3 radiation pneumonitis that resolved with steroids.

  • 5

    HT-based WLI with SIB demonstrates excellent target coverage and organ-at-risk sparing, but caution is advised regarding radiation pneumonitis risk.

Original Source(s)

Case report: Helical tomotherapy-based whole lung irradiation with simultaneous integrated boost for pulmonary metastatic Ewing’s sarcoma: a case series report and feasibility analysis

  • by YuanYou Yang, Lu Xie, Jie Xu, Xin Sun, Gang Ren

  • May 20, 2026

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