Global, regional, and national burden of pathogen-attributable infectious diseases in children by age and sex, 1990–2021: a systematic analysis - Takeaways - MDSpire

Global, regional, and national burden of pathogen-attributable infectious diseases in children by age and sex, 1990–2021: a systematic analysis

  • By

  • Xin Zhao

  • Zenghou Liu

  • Yanwei Wang

  • Yanhua Wang

  • Wendi Zhang

  • Xiaoxin Wang

  • Dalu Song

  • Zhuohui Zhao

  • Xin Liu

  • June 8, 2026

  • 0 min

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  • 1

    Infectious diseases significantly contribute to the global pediatric disease burden, especially in resource-limited settings.

  • 2

    Improvements in vaccination programs have reduced mortality from vaccine-preventable diseases, but disparities in coverage persist.

  • 3

    The study analyzed data from 204 countries to evaluate the impact of 34 pathogens on child mortality and disability from 1990 to 2021.

  • 4

    Pathogen-specific estimates were derived using a syndrome-based modeling strategy rather than direct laboratory-confirmed data.

  • 5

    The Sociodemographic Index was used to explore the relationship between socioeconomic development and pathogen-attributable disease burden.

Original Source(s)

Global, regional, and national burden of pathogen-attributable infectious diseases in children by age and sex, 1990–2021: a systematic analysis

  • by Xin Zhao, Zenghou Liu, Yanwei Wang, Yanhua Wang, Wendi Zhang, Xiaoxin Wang, Dalu Song, Zhuohui Zhao, Xin Liu

  • June 8, 2026

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