The interplay between epidermal cells and the cutaneous sensory nervous: a systematic review

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The skin is a complex sensory organ with intricate neural networks that facilitate sensory perception and immune defense.
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Epidermal cells and sensory neurons engage in bidirectional crosstalk, influencing each other's functional activities.
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Chemical signaling and immune response regulation are key mechanisms underlying the interactions between epidermal cells and sensory nerves.
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Neurological dysfunctions can exacerbate skin conditions, while chronic skin disorders may contribute to neurological issues.
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Understanding the crosstalk between epidermal cells and sensory nerves may provide insights for treating neurogenic skin diseases.

Frontiers In Immunology

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