Cholinergic regulation of neuroinflammation: linking microglia, immunometabolism, and neuromodulation - Takeaways - MDSpire
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Cholinergic Influence on Neuroinflammation: Connecting Microglial Activity, Immunometabolic Processes, and Neuromodulatory Mechanisms

  • By

  • Hui Guo

  • Ziyu Yang

  • Long Cheng

  • June 19, 2026

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  • 1

    Neuroinflammation is a key pathological process in various neurological diseases, influencing disease progression and treatment response.

  • 2

    Microglia serve as the primary immune cells in the CNS, undergoing dynamic changes that can either promote repair or exacerbate damage.

  • 3

    The cholinergic anti-inflammatory pathway links neural activity with immune regulation, affecting microglial activation and inflammatory responses.

  • 4

    Cholinergic signaling interacts with microglial biology and immune metabolism, influencing cytokine release and metabolic processes.

  • 5

    Emerging therapeutic strategies include targeting cholinergic receptors and vagus nerve stimulation to modulate neuroinflammation.

Original Source(s)

Cholinergic regulation of neuroinflammation: linking microglia, immunometabolism, and neuromodulation

  • by Hui Guo, Ziyu Yang, Long Cheng

  • June 19, 2026

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