Treatment non-persistence in children and adolescents with Tourette syndrome newly treated with dopamine D2 receptor modulators - Takeaways - MDSpire

Treatment non-persistence in children and adolescents with Tourette syndrome newly treated with dopamine D2 receptor modulators

  • By

  • Kinga K. Tomczak

  • Jason P. Swindle

  • Firas M. Dabbous

  • Donald L. Gilbert

  • George B. Karkanias

  • Sarah D. Atkinson

  • Frederick E. Munschauer

  • Faizan Mazhar

  • Charlotte A. Pettersson

  • Stephen P. Wanaski

  • Timothy M. Cunniff

  • David A. Isaacs

  • June 2, 2026

  • 0 min

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  • 1

    Dopamine D2 receptor antagonists/partial agonists are prescribed for Tourette syndrome in pediatric patients.

  • 2

    A study analyzed data from over 119 million individuals to compare adverse events and healthcare resource utilization in TS patients.

  • 3

    The D2RA-exposed cohort showed a significant decline in medication records over 18 months and higher odds of adverse events.

  • 4

    Higher rates of healthcare resource utilization were observed in the D2RA-exposed cohort compared to the non-exposed cohort.

  • 5

    Findings suggest that D2RA treatment in pediatric TS patients is associated with increased adverse events and healthcare needs.

Original Source(s)

Treatment non-persistence in children and adolescents with Tourette syndrome newly treated with dopamine D2 receptor modulators

  • by Kinga K. Tomczak, Jason P. Swindle, Firas M. Dabbous, Donald L. Gilbert, George B. Karkanias, Sarah D. Atkinson, Frederick E. Munschauer, Faizan Mazhar, Charlotte A. Pettersson, Stephen P. Wanaski, Timothy M. Cunniff, David A. Isaacs

  • June 2, 2026

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