Bivalent virus-like particles expressing SPECT1 and CSP trigger pre-erythrocytic malaria immunity and protect against transgenic Plasmodium falciparum sporozoite challenge in mice - Takeaways - MDSpire

Bivalent virus-like particles expressing SPECT1 and CSP trigger pre-erythrocytic malaria immunity and protect against transgenic Plasmodium falciparum sporozoite challenge in mice

  • By

  • Gulbuse Turan

  • Ekta Mukhopadhyay

  • Adam Truby

  • Kseniia Fedorova

  • Marco Polo Peralta Alvarez

  • Naif Khalaf Alharbi

  • Adrian V. S. Hill

  • Ahmed M. Salman

  • May 14, 2026

  • 0 min

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  • 1

    Bivalent virus-like particles incorporating SPECT1 and CSP enhance immune response against malaria in murine models.

  • 2

    The study engineered recombinant HBsAg VLPs displaying PfSPECT-1 and CSP, showing effective co-display of antigens.

  • 3

    One bivalent VLP candidate (N4) matched R21 efficacy with Matrix-M adjuvant, while another candidate (N2) was less effective.

  • 4

    NANP-specific IgG response correlated negatively with blood-stage parasite load, indicating potential for improved malaria immunity.

  • 5

    The modular HBsAg VLP platform allows for incorporation of antigens from various Plasmodium species, enhancing vaccine development.

Original Source(s)

Bivalent virus-like particles expressing SPECT1 and CSP trigger pre-erythrocytic malaria immunity and protect against transgenic Plasmodium falciparum sporozoite challenge in mice

  • by Gulbuse Turan, Ekta Mukhopadhyay, Adam Truby, Kseniia Fedorova, Marco Polo Peralta Alvarez, Naif Khalaf Alharbi, Adrian V. S. Hill, Ahmed M. Salman

  • May 14, 2026

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